Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful
Across 3 studies, all reported beneficial effects of Lactobacillus casei PXN 37 on reducing inflammation, with 2 of 3 reaching statistical significance. The predominant effect size is moderate, observed primarily in patient populations with autoimmune, neurodegenerative, or depression-related conditions. Effect sizes ranged from small to moderate, and study durations were not consistently reported.
- Studied populations: patients with autoimmune diseases, patients with neurodegenerative diseases (AD, PD, MS, and MCI), depressed patients with somatic comorbidities
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). One study found benefit only in a subgroup (depressed patients with somatic comorbidities), suggesting effects may not be universal.
Generated May 12, 2026