Research synthesisModerate evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful
Across 3 studies, all reported beneficial effects of Lactobacillus casei PXN 37 on reducing inflammation, with 2 out of 3 showing statistically significant results. The predominant effect size is moderate, with one study showing a small effect limited to a specific subgroup. Evidence is strongest for patients with autoimmune diseases (meta-analysis, n=703), where moderate reductions in IL-6, TNFα, and hs-CRP were observed.
- Studied populations: patients with autoimmune diseases; depressed patients with somatic comorbidities
Caveats: Only 3 studies are available, and two are meta-analyses with overlapping populations, which may inflate consistency. One study reported a small effect only in a subgroup (depressed patients with somatic comorbidities), and the third study (narrative review) did not provide effect size or significance. Doses and study durations were not consistently reported, limiting dose-response conclusions.
Generated May 11, 2026