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Evidence-Based Supplement Research
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Bifidobacterium lactis Bb-02 and Reduced Inflammation

Research synthesisLow evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Bifidobacterium lactis Bb-02 on reducing inflammation, with effect sizes ranging from small to moderate. The highest-quality evidence comes from a large meta-analysis (n=3390) in type 2 diabetes patients, which found reductions in CRP and TNF-α alongside increases in the anti-inflammatory cytokine IL-10. Effects in other populations (gestational diabetes, neurodegenerative diseases) were based on small or qualitative reviews.

  • Studied populations: people with type 2 diabetes, women with gestational diabetes, patients with neurodegenerative diseases

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. None of the studies reported statistical significance for Bifidobacterium lactis Bb-02 specifically, and dose and form data were not extracted, limiting practical guidance.

Generated Jun 11, 2026
3 of 3 papers
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