Lactobacillus casei PXN 37 and Increased Serum BDNF Levels

• Impact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis.

  • 2025-08-11
  • Systematic Review · n = 2,372
  • BMC nutrition 11(1)
  • • Reza Hashemi
    • Mohammad M Hussein M Raouf
    • Tanya S Salih
    • Marzieh Feyzpour
    • Maryam Eskandarioun
    • Najmeh Nezamabadipour
    • Hossein Gandomkar

  • PubMed: 40790243
  • DOI: 10.1186/s40795-025-01152-9

  1 Insight on

  • Increased Serum BDNF Levels

  • High evidence

  “Probiotic supplementation significantly increased serum BDNF levels (WMD = 0.18, 95% CI: 0.11–0.26; P < 0.001)”

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes