Lactobacillus casei culture supernatant ameliorates acute alcohol-induced liver injury by inhibiting cellular stress and promoting intestinal integrity in mice.
- 2026-04-03
- PloS one 21(4)
- Xie Zhang
- Zhihui Xu
- Ying You
- Longteng Xie
- Yongsheng Jiang
- Junyue Chen
- Zeping Xu
- Feng Xu
- Deshu Zhou
- PubMed: 41931531
- DOI: 10.1371/journal.pone.0344960
- Low evidence
- Animal Study
L. casei supernatants pretreatment significantly increased alcohol-reduced mRNA expression of zonula occludens-1, claudin-1, intestine trefoil factor, P-glycoprotein, and cathelin-related antimicrobial peptide. Consistently, the increased protein levels of ZO-1, occludin, and claudin-1 were confirmed by immunofluorescence.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes