Lactobacillus crispatus LV5 and Reduced Inflammatory Response

• Probiotic Properties of Lactobacillus crispatus 2,029: Homeostatic Interaction with Cervicovaginal Epithelial Cells and Antagonistic Activity to Genitourinary Pathogens

  • 2014-07-16
  • Probiotics and Antimicrobial Proteins 6(3-4)
  • • V. Abramov
    • V. Khlebnikov
    • I. Kosarev
    • Guldana Bairamova
    • R. Vasilenko
    • N. Suzina
    • A. Machulin
    • V. Sakulin
    • N. Kulikova
    • Nadezhda F. Vasilenko
    • A. V. Karlyshev
    • V. Uversky
    • M. Chikindas
    • V. Melnikov

  • PubMed: 25028263
  • DOI: 10.1007/s12602-014-9164-4

  15 Insights on

  • Reduced Inflammatory Response

  • Low evidence

  Lactobacillus crispatus 2029 did not induce expression of innate immunity mediators IL-8, IL-1β, IL-1α and TNF-α. Lactobacillus crispatus 2029 inhibited IL-8 production in epithelial cells induced by MALP-2 and increased production of anti-inflammatory cytokine IL-6, maintaining the homeostasis of female reproductive tract.

  Effect

  Beneficial

  Effect size

  Moderate