Lactobacillus crispatus VPro 31 and Reduced Proinflammatory Cytokine Production

• S-layer protein 2 of Lactobacillus crispatus 2029, its structural and immunomodulatory characteristics and roles in protective potential of the whole bacteria against foodborne pathogens.

  • 2020-05
  • International Journal of Biological Macromolecules 150
  • • V. Abramov
    • I. Kosarev
    • T. Priputnevich
    • A. Machulin
    • V. Khlebnikov
    • S. Pchelintsev
    • R. Vasilenko
    • V. Sakulin
    • N. Suzina
    • I. Chikileva
    • Evgenia I Derysheva
    • V. Melnikov
    • I. N. Nikonov
    • V. A. Samoilenko
    • Eduard E Svetoch
    • G. Sukhikh
    • V. Uversky
    • A. V. Karlyshev

  • PubMed: 32045605
  • DOI: 10.1016/j.ijbiomac.2020.02.065

  16 Insights on

  • Reduced Proinflammatory Cytokine Production

  • Low evidence

  Slp2 and LC2029 inhibited Il-8 production in Caco-2 and HT-29 cells induced by MALP-2.

  Effect

  Beneficial

  Effect size

  Moderate

• Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to Chlamydia trachomatis infection in vitro.

  • 2015-12
  • International Journal of Medical Microbiology 305(8)
  • • A. Rizzo
    • M. Fiorentino
    • E. Buommino
    • G. Donnarumma
    • A. Losacco
    • N. Bevilacqua

  • PubMed: 26372530
  • DOI: 10.1016/j.ijmm.2015.07.005

  7 Insights on

  • Reduced Proinflammatory Cytokine Production

  • Low evidence

  Our study then showed that L. crispatus and its supernatant reduced IL-6, IL-8 and TNF-α production in C. trachomatis-infected HeLa and J774 cells.

  Effect

  Beneficial

  Effect size

  Moderate