Lactobacillus fermentum CECT5716 and Reduced Crying Time

Doses used in studies

With B. Breve Cect7263 · CFU/day: 100 million (median 100 million, IQR 100 million–100 million) — 1 study
CFU/day: 100 million (median 100 million, IQR 100 million–100 million) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
All the products used in the study were safe and well tolerated.
from: Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, p
Overall tolerabilityReported
All the products used in the study were safe and well tolerated.
from: Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, p

2 of 2 papers

Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial.
- 2021-02-24
- RCT · n = 150
- Beneficial microbes 12(1)
- - J A Maldonado-Lobón
  - R Blanco-Rojo
  - J Maldonado
  - M A Ali
  - M V Almazán
  - A Suanes-Cabello
  - E Callejón
  - R Jaldo
  - M R Benavídes
  - A M Negrillo
  - A Sañudo
  - C Rodríguez
  - O Bañuelos
  - J Fonollá
  - M Olivares
- PubMed: 33350361
- DOI: 10.3920/bm2020.0105
1 Insight on
- Reduced Crying Time
- High evidence
- Large Human Trial
- Rigorous Journal
- Infants
the infants in the Bb group had significantly decreased crying time from the first week of the study (P<0.05), whereas the Bb+Lf group and the simethicone group had significantly decreased crying time from the second week (P<0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
1×10^8 cfu/day (as part of combination Bb+Lf group with B. breve CECT7263 at same dose)
Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial.
- 2021-02-24
- RCT · n = 150
- Beneficial Microbes 12(1)
- - J. Maldonado-Lobón
  - R. Blanco-Rojo
  - J. Maldonado
  - M. A. Ali
  - M. V. Almazán
  - A. Suanes-Cabello
  - E. Callejón
  - R. Jaldo
  - M. R. Benavides
  - A. Negrillo
  - A. Sañudo
  - C. Rodríguez
  - O. Bañuelos
  - J. Fonollá
  - M. Olivares
- PubMed: 33350361
- DOI: 10.3920/BM2020.0105
4 Insights on
- Reduced Crying Time
- High evidence
- Infants
The percentage of reduction in the minutes of crying from baseline in the Bb group was significantly higher than that in the Simethicone group every week of the intervention (-40.3 vs -27.6% at 1-week; -59.2 vs -43.2% at 2-weeks; -64.5 vs -53.5% at 3-week and -68.5 vs -59.5% at 4-weeks, P<0.05).
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
1×10^8 cfu/day

Lactobacillus fermentum CECT5716 and Reduced Crying Time

Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial.

Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial.