Lactobacillus fermentum ME-3 and Reduced Pathogenic Bacterial Activity

• Probiotic cell-free supernatants as a strategy against antimicrobial resistance: a systematic review.

  • 2026-03-02
  • Systematic Review
  • Frontiers in cellular and infection microbiology 16
  • • Maisah Meyhr D'Carmo Sodré
    • Ian David Araújo Cruz
    • Uener Ribeiro Santos
    • Sheila Cristina Potente Dutra Luquetti
    • Vânia Lúcia Silva
    • Alessandra Barbosa Ferreira Machado
    • Cláudio Galuppo Diniz
    • Cláudio Teodoro de Souza
    • Carla Cristina Romano
    • Lauro Juliano Marin
    • Luciana Debortoli de Carvalho

  • PubMed: 41847440
  • DOI: 10.3389/fcimb.2026.1731341

  1 Insight on

  • Reduced Pathogenic Bacterial Activity

  • High evidence

  Studies... evaluated antimicrobial activity, biofilm inhibition, and efficacy in biological and technological models against multidrug-resistant pathogens... The reviewed studies also demonstrated favorable physicochemical stability of L. fermentum cell-free derivatives, supporting their safety and scalability for applied use.

  Effect

  Beneficial

  Effect size

  Moderate