Lactobacillus gasseri BNR17 and Reduced Leptin Levels

• Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials.

  • 2025-04-23
  • Meta-Analysis · n = 58
  • Narra J 5(2)
  • • Juan Ajmn Lele
    • Karlos B Sihaloho
    • Dewa Vighneshwara
    • Derren Dch Rampengan
    • Chrisandi Y Rizqiansyah
    • Happy K Permatasari
    • Nelly Mayulu
    • Trina E Tallei
    • Nurpudji A Taslim
    • Bonglee Kim
    • Immanuelle Kezia
    • Fahrul Nurkolis
    • Rony A Syahputra

  • PubMed: 40951500
  • DOI: 10.52225/narra.v5i2.1562

  9 Insights on

  • Reduced Leptin Levels

  • High evidence

  Leptin levels significantly decreased (MD: -2.11 μg/mL; 95%CI: -3.59-(-0.64), p=0.005) compared to before Lactobacillus sp. supplementation

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice

  • 2013-01-30
  • Clinical Trial
  • PLoS ONE 8(1)
  • • Ji-hee Kang
    • S. Yun
    • Miri Park
    • Jun-Hong Park
    • So-Young Jeong
    • Han-Oh Park

  • PubMed: 23382926
  • DOI: 10.1371/journal.pone.0054617

  7 Insights on

  • Reduced Leptin Levels

  • Low evidence
  • Highly Cited
  • Rigorous Journal
  • Animal Study

  L. gasseri BNR17 also reduced the levels of leptin and insulin in serum.

  Effect

  Beneficial

  Effect size

  Moderate