Lactobacillus helveticus R0052-derived membrane vesicles ameliorate DSS-induced inflammatory bowel disease by modulating the gut microbiota and activating the cholinergic anti-inflammatory pathway.
- 2026-02
- International immunopharmacology 171
- Chinasa Valerie Olovo
- Ying Ji
- Dickson Kofi Wiredu Ocansey
- Xinxiang Huang
- Min Xu
- PubMed: 41512794
- DOI: 10.1016/j.intimp.2025.116058
- Low evidence
- Animal Study
16S rDNA and UHPLC/Orbitrap mass spectrometry analyses showed that 052-MVs improved the gut microbiota structure and diversity and mitigated DSS-induced metabolite dysregulation.
- Effect
- Beneficial
- Effect size
- Moderate