Lactobacillus paracasei 431 and Reduced Oral Pain

• Probiotic supplementation attenuates dental pain and inhibits pain-induced cognitive impairment in male rats.

  • 2025-11
  • RCT · n = 8
  • Archives of oral biology 179
  • • Pegah Abazari-Bozhgani
    • Saeed Esmaeili-Mahani
    • Mehdi Abbasnejad
    • Maryam Raoof
    • Frank Lobbezoo

  • PubMed: 40902425
  • DOI: 10.1016/j.archoralbio.2025.106382

  2 Insights on

  • Reduced Oral Pain

  • Low evidence
  • Animal Study

  Probiotics could attenuate nociception and prevent IL-1β and TNF-α overexpression.

  Effect

  Beneficial

  Effect size

  Moderate