Efficacy and Safety of Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2019-02-01
RCT · n = 100
Nutrients 11(2)
- Yun-Ha Hwang
- Shinwon Park
- J. Paik
- S. Chae
- Dong-Hyun Kim
- Doc-Gyun Jeong
- Eunji Ha
- Myeongju Kim
- Gahae Hong
- Soo-Hyun Park
- Su-Jin Jung
- Sang-Min Lee
- Kyu-Heum Na
- Jungyoon Kim
- Young-Chul Chung

PubMed: 30717153
DOI: 10.3390/nu11020305

Improved Cognitive Function

High evidence
Highly Cited
Clinical

The primary outcome measure was change in the composite score of cognitive functions related to memory and attention, measured by computerized neurocognitive function tests. Compared to the placebo group, the DW2009 group showed greater improvements in the combined cognitive functions (z = 2.36, p for interaction = 0.02), especially in the attention domain (z = 2.34, p for interaction = 0.02).

Effect: Beneficial
Effect size: Moderate
Significant: Yes

Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study.

2019-04-19
RCT · n = 111
Beneficial Microbes 10(4)
- H. Chong
- Nor Azizi Yusoff
- Y. Hor
- L. Lew
- M. Jaafar
- S. Choi
- Muhamad Saiful Bahri Yusoff
- N. Wahid
- Mohammad Farris Iman Leong Bin Abdullah
- Norzila Zakaria
- Kee-Leong Ong
- Y. Park
- M. Liong

PubMed: 30882244
DOI: 10.3920/BM2018.0135

16 Insights on

Improved Cognitive Function

High evidence
Highly Cited

DR7 better improved cognitive and memory functions in normal adults (>30 years old), such as basic attention, emotional cognition, and associate learning (P<0.05)

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 1×10^9 cfu/day