Lactobacillus plantarum DR7 and Improved Gut Microbiota Diversity

• Lactobacillus plantarum DR7 Modulated Bowel Movement and Gut Microbiota Associated with Dopamine and Serotonin Pathways in Stressed Adults

  • 2020-06-29
  • RCT
  • International Journal of Molecular Sciences 21(13)
  • • Guoxia Liu
    • H. Chong
    • F. Chung
    • Yin Li
    • M. Liong

  • PubMed: 32610495
  • DOI: 10.3390/ijms21134608

  2 Insights on

  • Improved Gut Microbiota Diversity

  • High evidence

  Over 12 weeks, alpha diversity of gut microbiota was higher in DR7 than the placebo group across class (*p* = 0.005) and order (*p* = 0.018) levels.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Lactobacillus probiotics improved the gut microbiota profile of a Drosophila melanogaster Alzheimer's disease model and alleviated neurodegeneration in the eye.

  • 2020-02-19
  • Clinical Trial
  • Beneficial Microbes 11(1)
  • • F. Tan
    • G. Liu
    • S. A. Lau
    • M. Jaafar
    • Y. Park
    • G. Azzam
    • Y. Li
    • M. Liong

  • PubMed: 32066253
  • DOI: 10.3920/bm2019.0086

  2 Insights on

  • Improved Gut Microbiota Diversity

  • Low evidence
  • Animal Study

  The administration of DR7 restored the gut microbiota diversity of AD-induced *Drosophila* with a significant reduction in *Wolbachia*'s relative abundance, accompanied by an increase of *Stenotrophomonas* and *Acetobacter*.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes