Lactobacillus plantarum DR7 and Reduced TNF-α Levels

• Meta-Analysis: Randomized Trials of Lactobacillus plantarum on Immune Regulation Over the Last Decades

  • 2021-03-22
  • Meta-Analysis
  • Frontiers in Immunology 12
  • • Wei Zhao
    • Chuantao Peng
    • H. A. Sakandar
    • L. Kwok
    • Wenyi Zhang

  • PubMed: 33828554
  • DOI: 10.3389/fimmu.2021.643420

  13 Insights on

  • Reduced TNF-α Levels

  • High evidence

  The mean differences observed at 95% confidence interval: tumor necrosis factor (TNF)-α, -2.34 pg/mL (-3.5 to -1.19; *p* < 0.05)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Lactobacillus plantarum B7 inhibits Helicobacter pylori growth and attenuates gastric inflammation.

  • 2012-12-07
  • RCT
  • World Journal of Gastroenterology 18(20)
  • • Chompoonut Sunanliganon
    • D. Thong-ngam
    • S. Tumwasorn
    • N. Klaikeaw

  • PubMed: 22654444
  • DOI: 10.3748/wjg.v18.i20.2472

  3 Insights on

  • Reduced TNF-α Levels

  • Low evidence
  • Rigorous Journal
  • Animal Study

  The serum TNF-α level was significant decreased in group 3 compared with group 2 (P < 0.05).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes