Meta-Analysis: Randomized Trials of Lactobacillus plantarum on Immune Regulation Over the Last Decades
- 2021-03-22
- Frontiers in Immunology 12
- Wei Zhao
- Chuantao Peng
- H. A. Sakandar
- L. Kwok
- Wenyi Zhang
- PubMed: 33828554
- DOI: 10.3389/fimmu.2021.643420
Abstract
Lactobacillus (L.) plantarum strains, belong to lactic acid bacteria group, are considered indispensable probiotics. Here, we performed meta-analysis to evaluate the regulatory effects of L. plantarum on the immunity during clinical trials. This meta-analysis was conducted by searching across four most common literature databases, namely, Cochrane Central Register of Controlled Trials, Web of Science, Embase, and PubMed. Clinical trial articles that met the inclusion and exclusion criteria were analyzed by Review Manager (version 5.3). p-value < 0.05 of the total effect was considered statistically significant. Finally, total of 677 references were retrieved, among which six references and 18 randomized controlled trials were included in the meta-analysis. The mean differences observed at 95% confidence interval: interleukin (IL)-4, -0.48 pg/mL (-0.79 to -0.17; p < 0.05); IL-10, 9.88 pg/mL (6.52 to 13.2; p < 0.05); tumor necrosis factor (TNF)-α, -2.34 pg/mL (-3.5 to -1.19; p < 0.05); interferon (IFN)-γ, -0.99 pg/mL (-1.56 to -0.41; p < 0.05). Therefore, meta-analysis results suggested that L. plantarum could promote host immunity by regulating pro-inflammatory and anti-inflammatory cytokines.
Keywords: IFN-γ; IL-10; IL-4; Lactobacillus plantarum; TNF-α; immunity; meta-analysis.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Altered IL-4 Levels | Beneficial | Moderate |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Increased IL-10 Levels | Beneficial | Large |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Reduced IFN-γ Levels | Beneficial | Small |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum | Increased IL-10 Levels | Beneficial | Large |
| Lactobacillus plantarum | Reduced IFN-γ Levels | Beneficial | Small |
| Lactobacillus plantarum | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Increased Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum 14D | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum DR7 | Increased Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum DR7 | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum DR7 | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum DR7 | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Elevated Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Interleukin-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Elevated Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum DSM 6596 | Reduced IFN-γ Levels | Beneficial | Small |
| Lactobacillus plantarum DSM 6596 | Reduced Interleukin-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Lactobacillus plantarum HA-119 | Increased Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum HA-119 | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum HA-119 | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum HA-119 | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum KABP™-061 | Altered IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum KABP™-061 | Increased IL-10 Levels | Beneficial | Large |
| Lactobacillus plantarum KABP™-061 | Reduced IFN-γ Levels | Beneficial | Small |
| Lactobacillus plantarum KABP™-061 | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum L-137 | Increased Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum L-137 | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum L-137 | Reduced Interleukin-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum L-137 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Lactobacillus plantarum LP-01 | Increased Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum LP-01 | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum LP-01 | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum LP-01 | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum Lp-115 | Improved Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum Lp-115 | Improved Interleukin-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum Lp-115 | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum Lp-115 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Lactobacillus plantarum N13 | Reduced IFN-γ Levels | Beneficial | Small |
| Lactobacillus plantarum N13 | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Increased IL-10 Levels | Beneficial | Large |
| Lactobacillus plantarum Rosell-1012 | Reduced IFN-γ Levels | Beneficial | Small |
| Lactobacillus plantarum Rosell-1012 | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | Increased IL-10 Levels | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Reduced IFN-γ Levels | Beneficial | Small |
| Lactobacillus plantarum Rosell-A | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Increased Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum SD-5209 | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Increased Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Reduced Interferon-Gamma Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Interleukin-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Tumor Necrosis Factor Alpha | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Decreased IFN-γ Levels | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Increased Interleukin-10 Levels | Beneficial | Large |
| Lactobacillus plantarum UALp-05M | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Reduced TNF-α Levels | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Increased IL-10 Levels | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Reduced IFN-γ Levels | Beneficial | Small |
| Lactobacillus plantarum VPro 10 | Reduced IL-4 Levels | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced TNF-α Levels | Beneficial | Moderate |