Lactobacillus plantarum HEAL9 and Improved Depressive Symptoms

• Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study.

  • 2020-06-25
  • RCT · n = 90
  • The Primary Care Companion For CNS Disorders 22(4)
  • • A. Saccarello
    • Paolo Montarsolo
    • Ivano Massardo
    • R. Picciotto
    • A. Pedemonte
    • R. Castagnaro
    • P. Brasesco
    • Vittorio Guida
    • P. Picco
    • P. Fioravanti
    • R. Montisci
    • I. Schiavetti
    • A. Vanelli

  • PubMed: 32589828
  • DOI: 10.4088/pcc.19m02578

  5 Insights on

  • Improved Depressive Symptoms

  • High evidence

  A greater reduction for the new combination compared to placebo was seen at treatment week 6 in the Z-SDS total score (P = .0165) and the core depression subdomain (P = .0247). A significant reduction in favor of the combination was shown at treatment week 2 for the Z-SDS total score (P = .0330), the cognitive and anxiety subdomains (P = .0133 and P = .0459, respectively), and the anxiety questionnaire (P = .0345).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes