Lactobacillus plantarum HEAL9 and Reduced Depression Symptoms

• Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults.

  • 2025-06-17
  • Review
  • Nutrients 17(12)
  • • Alexandra-Eleftheria Menni
    • Helen Theodorou
    • Georgios Tzikos
    • Ioannis M Theodorou
    • Eleni Semertzidou
    • Veroniki Stelmach
    • Anne D Shrewsbury
    • George Stavrou
    • Katerina Kotzampassi

  • PubMed: 40573133
  • DOI: 10.3390/nu17122022

  4 Insights on

  • Reduced Depression Symptoms

  • Moderate evidence
  • Rigorous Journal

  Nineteen RCTs met the inclusion criteria, with all demonstrating a significant amelioration of depression status after probiotic/psychobiotic treatment... Probiotics, particularly multi-strain preparations and certain well-characterized single strains, seem to be noticeably beneficial in alleviating depressive symptoms in adults.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes