Lactobacillus plantarum KABP-061 and Reduced Epithelial Permeability

• Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier.

  • 2010-06
  • RCT
  • American Journal of Physiology-Gastrointestinal and Liver Physiology 298(6)
  • • J. Karczewski
    • F. Troost
    • I. Konings
    • J. Dekker
    • M. Kleerebezem
    • R. Brummer
    • J. Wells

  • PubMed: 20224007
  • DOI: 10.1152/ajpgi.00327.2009

  9 Insights on

  • Reduced Epithelial Permeability

  • High evidence
  • Highly Cited
  • Adults

  Pretreatment of Caco-2 monolayers with L. plantarum or PCSK significantly attenuated the effects of phorbol ester-induced dislocation of ZO-1 and occludin and the associated increase in epithelial permeability.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes