Lactobacillus plantarum L-137 and Increased Hyaluronic Acid Synthesis in Fibroblasts

• Lactobacillus plantarum L‐137 upregulates hyaluronic acid production in epidermal cells and fibroblasts in mice

  • 2019-07-29
  • Clinical Trial
  • Microbiology and Immunology 63(9)
  • • Hiroko Nakai
    • Y. Hirose
    • S. Murosaki
    • Y. Yoshikai

  • PubMed: 31273816
  • DOI: 10.1111/1348-0421.12725

  5 Insights on

  • Increased Hyaluronic Acid Synthesis in Fibroblasts

  • Low evidence
  • Animal Study

  Supernatant from immune cells stimulated by HK L-137... upregulated HA production and hyaluronan synthase 2 (HAS2) messenger RNA expression by BALB/3T3 fibroblasts

  Effect

  Beneficial

  Effect size

  Moderate