Lactobacillus plantarum L-137 and Reduced Inflammation in Adipose Tissue

• Heat-killed Lactobacillus plantarum L-137 attenuates obesity and associated metabolic abnormalities in C57BL/6 J mice on a high-fat diet

  • 2021-05-18
  • Clinical Trial
  • Bioscience of Microbiota, Food and Health 40(2)
  • • Rieko Yoshitake
    • Y. Hirose
    • S. Murosaki
    • G. Matsuzaki

  • PubMed: 33996364
  • DOI: 10.12938/bmfh.2020-040

  10 Insights on

  • Reduced Inflammation in Adipose Tissue

  • Low evidence
  • Rigorous Journal
  • Animal Study

  Expression of several inflammation-related genes, including F4/80, CD11c, and IL-1β, in the epididymal adipose tissue of these mice was significantly downregulated by HK L-137.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Anti-inflammatory effects of heat-killed Lactobacillus plantarum L-137 on cardiac and adipose tissue in rats with metabolic syndrome.

  • 2018-05-25
  • Scientific reports 8(1)
  • • Ayako Uchinaka
    • Naoki Azuma
    • Hisashi Mizumoto
    • Shiho Nakano
    • Moeko Minamiya
    • Mamoru Yoneda
    • Kiyoshi Aoyama
    • Yuki Komatsu
    • Yuichiro Yamada
    • Toyoaki Murohara
    • Kohzo Nagata

  • PubMed: 29802339
  • DOI: 10.1038/s41598-018-26588-x

  5 Insights on

  • Reduced Inflammation in Adipose Tissue

  • Low evidence
  • Rigorous Journal
  • Animal Study

  as well as adipocyte hypertrophy, inflammation, and up-regulation of sterol regulatory element-binding protein-1c (SREBP-1c) gene expression in visceral and subcutaneous adipose tissue

  Effect

  Beneficial

  Effect size

  Moderate