Anti-inflammatory effects of heat-killed Lactobacillus plantarum L-137 on cardiac and adipose tissue in rats with metabolic syndrome.
- 2018-05-25
- Scientific reports 8(1)
- Ayako Uchinaka
- Naoki Azuma
- Hisashi Mizumoto
- Shiho Nakano
- Moeko Minamiya
- Mamoru Yoneda
- Kiyoshi Aoyama
- Yuki Komatsu
- Yuichiro Yamada
- Toyoaki Murohara
- Kohzo Nagata
- PubMed: 29802339
- DOI: 10.1038/s41598-018-26588-x
Study Design
- Population
- DahlS.Z-Lepr fa /Lepr fa (DS/obese) rats as a model of metabolic syndrome
- Methods
- DS/obese rats were treated orally with HK L-137 (2 or 75 mg kg-1 day-1) from 9 to 13 weeks of age
- Rigorous Journal
- Animal Study
The effects of heat-killed Lactobacillus plantarum L-137 (HK L-137) on chronic inflammation associated with metabolic disorders have remained unknown. We examined the effects of HK L-137 on cardiac and adipose tissue pathophysiology in DahlS.Z-Lepr fa /Lepr fa (DS/obese) rats as a model of metabolic syndrome. DS/obese rats were treated orally with HK L-137 (2 or 75 mg kg-1 day-1) from 9 to 13 weeks of age. HK L-137 attenuated left ventricular (LV) inflammation and fibrosis as well as adipocyte hypertrophy, inflammation, and up-regulation of sterol regulatory element-binding protein-1c (SREBP-1c) gene expression in visceral and subcutaneous adipose tissue, without affecting body weight gain or hypertension. The low dose of HK L-137 also ameliorated LV diastolic dysfunction, the increase in subcutaneous fat mass, and insulin resistance as well as attenuated the down-regulation of Akt phosphorylation in visceral and subcutaneous adipose tissue, and the elevation of the circulating interleukin-6 concentration. Furthermore, the proportion of regulatory T (Treg) cells among CD4+ T cells in the spleen was increased by HK L-137. These results suggest that the anti-inflammatory effects of HK L-137 on the heart and adipose tissue are related, at least partly, to suppression of systemic inflammation associated with an increase in splenic Treg cell.
Research Insights
The low dose of HK L-137 also ameliorated LV diastolic dysfunction
- Effect
- Beneficial
- Effect size
- Small
The low dose of HK L-137 also ameliorated... insulin resistance
- Effect
- Beneficial
- Effect size
- Moderate
the proportion of regulatory T (Treg) cells among CD4+ T cells in the spleen was increased by HK L-137
- Effect
- Beneficial
- Effect size
- Small
as well as adipocyte hypertrophy, inflammation, and up-regulation of sterol regulatory element-binding protein-1c (SREBP-1c) gene expression in visceral and subcutaneous adipose tissue
- Effect
- Beneficial
- Effect size
- Moderate
and the elevation of the circulating interleukin-6 concentration
- Effect
- Beneficial
- Effect size
- Small