Lactobacillus plantarum Rosell-A and Improved Depressive Symptoms

• Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review.

  • 2025-06-27
  • Systematic Review
  • Nutrients 17(13)
  • • Angelika Śliwka
    • Magdalena Polak-Berecka
    • Kinga Zdybel
    • Agnieszka Zelek-Molik
    • Adam Waśko

  • PubMed: 40647242
  • DOI: 10.3390/nu17132139

  1 Insight on

  • Improved Depressive Symptoms

  • High evidence
  • Rigorous Journal

  Lactobacillus plantarum ... demonstrated particularly promising effects ... Psychobiotics show significant potential as adjunctive and therapeutic agents in depressive disorders through modulation of the gut-brain axis.

  Effect

  Beneficial

  Effect size

  Moderate

• Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults.

  • 2025-06-17
  • Review
  • Nutrients 17(12)
  • • Alexandra-Eleftheria Menni
    • Helen Theodorou
    • Georgios Tzikos
    • Ioannis M Theodorou
    • Eleni Semertzidou
    • Veroniki Stelmach
    • Anne D Shrewsbury
    • George Stavrou
    • Katerina Kotzampassi

  • PubMed: 40573133
  • DOI: 10.3390/nu17122022

  4 Insights on

  • Improved Depressive Symptoms

  • Moderate evidence
  • Rigorous Journal

  all demonstrating a significant amelioration of depression status after probiotic/psychobiotic treatment... In total, 7 out of 10 studies with probiotics as an add-on therapy ... exhibited a significant amelioration of depression status against placebo treatment.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes