All 3 studies reported beneficial effects on reduced blood cholesterol, with predominantly small effect sizes. The strongest evidence comes from a randomized controlled trial in hypercholesterolemic adults (n=127) showing a 9.14% reduction in total cholesterol (p<0.001). Dosage and study duration were not consistently reported across studies.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Study durations were not consistently reported.
total cholesterol by 9.14% (P<0.001) relative to placebo.
Strain subgroup analysis showed that L. reuteri NCIMB 30242 significantly reduced TC and LDL-C.
significantly reducing LDL-C and total cholesterol
LRC supplementation could alleviate the serum cholesterol level by inhibiting the intracellular cholesterol synthesis, and augmenting excretion of intestinal cholesterol.