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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lactobacillus reuteri and Improved Forced Expiratory Volume

Doses used in studies

CFU/day: 100 million (median 100 million, IQR 100 million–100 million) — 1 study

Time to effect

Median: 10.7 weeks · IQR 7.5 weeks–3.3 months · Range 4.3 weeks–4 months — Reported in 2 of 2 studies

2 of 2 papers

The impact of probiotics on pulmonary, gastrointestinal, and growth outcomes in pediatric cystic fibrosis: a randomized controlled trial.
- 2025-05-28
- RCT · n = 55
- BMC pediatrics 25(1)
- - Parisa Rahmani
  - Pejman Rohani
  - Arian Kariman
  - Farzaneh Motamed
  - Mohammad Reza Modaresi
  - Kambiz Eftekhari
  - Mehri Ayati
  - Mohammad Hassan Sohouli
- PubMed: 40437397
- DOI: 10.1186/s12887-025-05789-0
6 Insights on
- Improved Forced Expiratory Volume
- High evidence
- Clinical
no significant changes were observed between the two groups after 4 and 12 weeks regarding BMI and FEV1.
Effect
Neutral
Effect size
Small
Significant
No
Dose
10^8 CFU/d
The effect of Lactobacillus reuteri on pulmonary function test and growth of cystic fibrosis patients.
- 2024-07-10
- RCT · n = 40
- Journal of the science of food and agriculture 104(14)
- - Seyed Ahmad Tabatabaii
  - Ghamartaj Khanbabaee
  - Saeed Sadr
  - Nazanin Farahbakhsh
  - Seyedeh Zalfa Modarresi
  - Matin Pourghasem
  - Mahmoud Hajipour
- PubMed: 38982876
- DOI: 10.1002/jsfa.13732
10 Insights on
- Improved Forced Expiratory Volume
- High evidence
- Clinical
There was no significant difference in forced expiratory volume in the first second [...] change between the two groups after the treatment period (P > 0.05)
Effect
Neutral
Effect size
Small
Significant
No
Dose
daily for 4 months (specific dose not stated in abstract)