The effect of Lactobacillus reuteri on pulmonary function test and growth of cystic fibrosis patients.
- 2024-07-10
- Journal of the science of food and agriculture 104(14)
- Seyed Ahmad Tabatabaii
- Ghamartaj Khanbabaee
- Saeed Sadr
- Nazanin Farahbakhsh
- Seyedeh Zalfa Modarresi
- Matin Pourghasem
- Mahmoud Hajipour
- PubMed: 38982876
- DOI: 10.1002/jsfa.13732
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 40
- Population
- 40 children with CF aged from 6 to 20 years
- Methods
- A randomized, placebo-controlled clinical trial; participants received either L. reuteri or placebo daily for 4 months
- Blinding
- Double-blind
- Duration
- 4 months
- Funding
- Unclear
Introduction
Cystic fibrosis (CF) patients frequently experience gut microbiota dysbiosis. Probiotic supplementation is a potential therapeutic approach to modify gut microbiota and improve CF management through the gut-lung axis. The aim of this study was to investigate the effect of Lactobacillus reuteri supplementation on pulmonary function test, respiratory symptoms and growth in CF patients.Methods
A randomized, placebo-controlled clinical trial was carried out on 40 children with CF aged from 6 to 20 years. Participants were designated to receive either L. reuteri or placebo daily for 4 months. Pulmonary function tests, weight, height and body mass index (BMI) z-scores were measured pre and post treatment.Results
The median baseline BMI of the patients was 16.28 kg m-2. A significant change in the probiotic group's BMI z-score after the study period was observed (P = 0.034) but not for weight and height z-scores (P > 0.05). After treatment, Pseudomonas aeruginosa grew in sputum cultures of seven in the placebo and one patient in the intervention group (P = 0.03) while at baseline it grew in the sputum of four patients in each group. There was no significant difference in forced expiratory volume in the first second, forced expiratory flow at 25-75% or forced vital capacity change between the two groups after the treatment period (P > 0.05). Additionally, no significant differences were found in pulmonary exacerbations, hospitalization frequencies or COVID-19 infection between the two groups during the study (P > 0.05).Conclusion
The results suggest that L. reuteri supplementation may impact the growth of severely malnourished CF patients. Furthermore, it may be concluded that this strain might reduce P. aeruginosa in the sputum culture of CF patients. © 2024 Society of Chemical Industry.Research Insights
There was no significant difference in forced expiratory flow at 25-75% [...] change between the two groups after the treatment period (P > 0.05)
- Effect
- Neutral
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)
There was no significant difference in forced expiratory volume in the first second [...] change between the two groups after the treatment period (P > 0.05)
- Effect
- Neutral
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)
There was no significant difference in [...] forced vital capacity change between the two groups after the treatment period (P > 0.05)
- Effect
- Neutral
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)
not for weight and height z-scores (P > 0.05)
- Effect
- Neutral
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)
not for weight and height z-scores (P > 0.05)
- Effect
- Neutral
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)
A significant change in the probiotic group's BMI z-score after the study period was observed (P = 0.034)
- Effect
- Beneficial
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)
no significant differences were found in [...] COVID-19 infection between the two groups during the study (P > 0.05)
- Effect
- Neutral
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)
no significant differences were found in [...] hospitalization frequencies [...] between the two groups during the study (P > 0.05)
- Effect
- Neutral
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)
Pseudomonas aeruginosa grew in sputum cultures of seven in the placebo and one patient in the intervention group (P = 0.03)
- Effect
- Beneficial
- Effect size
- Moderate
- Dose
- daily for 4 months (specific dose not stated in abstract)
no significant differences were found in pulmonary exacerbations [...] between the two groups during the study (P > 0.05)
- Effect
- Neutral
- Effect size
- Small
- Dose
- daily for 4 months (specific dose not stated in abstract)