Lactobacillus reuteri and Reduced Probing Pocket Depth

• Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial.

  • 2025-08-26
  • RCT
  • Clinical oral investigations 29(9)
  • • Magda Mensi
    • Eleonora Scotti
    • Silvia Marchetti
    • Annamaria Sordillo
    • Gianluca Garzetti
    • Stefano Calza
    • Mark J Buijs
    • Egija Zaura
    • Bernd W Brandt

  • PubMed: 40856866
  • DOI: 10.1007/s00784-025-06508-w

  7 Insights on

  • Reduced Probing Pocket Depth

  • High evidence
  • Clinical

  Both groups showed a significant decrease in PPD, BOP, CAL, and number/percentage of residual pockets compared to baseline. However, no inter-group differences were noted.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  3 weeks of bi-daily supplementation with lozenges containing probiotic (specific CFU not stated in abstract)

• Clinical efficacy of Lactobacillus reuteri-containing lozenges in the supportive therapy of generalized periodontitis stage III and IV, grade C: 1-year results of a double-blind randomized placebo-controlled pilot study

  • 2019-10-16
  • RCT · n = 20
  • Clinical Oral Investigations 24(6)
  • • M. G. Grusovin
    • S. Bossini
    • S. Calza
    • V. Cappa
    • G. Garzetti
    • E. Scotti
    • E. Gherlone
    • M. Mensi

  • PubMed: 31620939
  • DOI: 10.1007/s00784-019-03065-x

  5 Insights on

  • Reduced Probing Pocket Depth

  • High evidence

  more PPD reduction at all time points (p < 0.05) ... were found in the probiotic group

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  2 lozenges/day