Lactobacillus rhamnosus GG and Reduced Necrotizing Enterocolitis Incidence

• Routine Supplementation of Lactobacillus rhamnosus GG and Risk of Necrotizing Enterocolitis in Very Low Birth Weight Infants.

  • 2018-04
  • Observational
  • The Journal of pediatrics 195
  • • Andrea F Kane
    • Anisha D Bhatia
    • Patricia W Denning
    • Andi L Shane
    • Ravi Mangal Patel

  • PubMed: 29402455
  • DOI: 10.1016/j.jpeds.2017.11.055

  1 Insight on

  • Reduced Necrotizing Enterocolitis Incidence

  • Low evidence
  • Infants

  In multivariable analysis, LGG supplementation was associated with a higher risk of necrotizing enterocolitis (aOR 2.10, 95 % CI 1.25-3.54, P = .005).

  Effect

  Harmful

  Effect size

  Large

  Significant

  Yes

  Dose

  2.5 to 5 × 10^9 CFU/day