Lactobacillus rhamnosus GG and Reduced Pain Frequency

• Comparative efficacy of probiotic, prebiotic, and synbiotic interventions in children with functional abdominal pain disorders: a systematic review and network meta-analysis.

  • 2026-03-10
  • Systematic Review
  • Frontiers in nutrition 13
  • • Yongrui Yang
    • Yunsong Li
    • Xiyu Yan
    • Wenrui Huang
    • Chunlan Cao
    • Haonan Yan
    • Li Leng

  • PubMed: 41883407
  • DOI: 10.3389/fnut.2026.1764837

  4 Insights on

  • Reduced Pain Frequency

  • High evidence
  • Clinical

  identified L. reuteri DSM 17938, L. rhamnosus GG, Bifidobacterium mix, and B. longum (DM8504) as the most effective

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights.

  • 2024-01-25
  • Review
  • Nutrients 16(3)
  • • Silvia Salvatore
    • Mariagrazia Carlino
    • Simona Sestito
    • Daniela Concolino
    • Massimo Agosti
    • Licia Pensabene

  • PubMed: 38337634
  • DOI: 10.3390/nu16030349

  5 Insights on

  • Reduced Pain Frequency

  • Moderate evidence
  • Rigorous Journal
  • Clinical

  for Lactobacillus rhamnosus GG (1-3 × 10^9 CFU twice daily) in reducing pain frequency and intensity in children with IBS

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  1-3 × 10^9 CFU twice daily