Lactobacillus rhamnosus GG and Shifted Tumor-Associated Macrophages Toward Pro-Inflammatory M1 Polarization

• INFLUENCE OF BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS BB-12 AND LACTOBACILLUS RHAMNOSUS GG ON POLARIZATION OF TUMOR-ASSOCIATED MACROPHAGES.

  • 2026-03-05
  • Experimental oncology 47(4)
  • • N Fedosova
    • T Symchych
    • S Gogol
    • N Cheremshenko
    • P Virych
    • I Voyeykova
    • V Chekhun

  • PubMed: 41788069
  • DOI: 10.15407/exp-oncology.2025.04.451

  1 Insight on

  • Shifted Tumor-Associated Macrophages Toward Pro-Inflammatory M1 Polarization

  • Low evidence
  • Animal Study

  The TAMs in the group supplemented with LGG demonstrated M1 polarization with low arginase activity but high production of NO and ROS, as well as cytotoxic activity toward Ehrlich carcinoma cells.

  Effect

  Beneficial

  Effect size

  Moderate