Lactobacillus rhamnosus LCS-742 and Decreased Peripheral T Cell Response

• Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function.

  • 2004-12
  • The American Journal of Clinical Nutrition 80(6)
  • • H. Braat
    • Jan M. H. Van den Brande
    • E. V. van Tol
    • D. Hommes
    • M. Peppelenbosch
    • S. V. van Deventer

  • PubMed: 15585777
  • DOI: 10.1093/AJCN/80.6.1618

  7 Insights on

  • Decreased Peripheral T Cell Response

  • Low evidence
  • Highly Cited

  A decreased T cell proliferation and cytokine production, especially of IL-2, IL-4, and IL-10, was observed in CD3/CD28-stimulated T cells derived from L. rhamnosus-matured DCs.

  Effect

  Beneficial

  Effect size

  Moderate