Lactobacillus rhamnosus LCS-742 and Improved Intestinal Barrier Function

• Lactobacillus rhamnosus GG Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction by Regulating MAPK/NF-κB Signaling and Modulating Metabolome in the Piglet Intestine.

  • 2020-05
  • RCT · n = 6
  • The Journal of Nutrition 150(5)
  • • Jiangdi Mao
    • Siri Qi
    • Yanjun Cui
    • Xiaoxiao Dou
    • Xin M. Luo
    • Jianxin Liu
    • T. Zhu
    • Yanfei Ma
    • Haifeng Wang

  • PubMed: 32027752
  • DOI: 10.1093/jn/nxaa009

  9 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study

  LGG pretreatment significantly enhanced the intestinal barrier by upregulating expressions of tight junction proteins (ZO-1, 73%; claudin-3, 55%; occludin, 67%); thereby decreasing serum diamineoxidase (26%) and D-xylose (28%) concentrations.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes