Lactobacillus rhamnosus LCS-742 and Reduced Enterocyte Damage

• Lactobacillus rhamnosus attenuates Thai chili extracts induced gut inflammation and dysbiosis despite capsaicin bactericidal effect against the probiotics, a possible toxicity of high dose capsaicin

  • 2021-12-23
  • RCT
  • PLOS ONE 16(12)
  • • Wimonrat Panpetch
    • Peerapat Visitchanakun
    • Wilasinee Saisorn
    • A. Sawatpanich
    • Piraya Chatthanathon
    • N. Somboonna
    • S. Tumwasorn
    • A. Leelahavanichkul

  • PubMed: 34941893
  • DOI: 10.1371/journal.pone.0261189

  17 Insights on

  • Reduced Enterocyte Damage

  • Low evidence
  • Rigorous Journal
  • Animal Study
  • Mixed

  Additionally, high concentrations of capsaicin (0.02-2 mM) damage enterocytes (Caco-2 and HT-29) as indicated by cell viability test, supernatant cytokine (IL-8), transepithelial electrical resistance (TEER) and transepithelial FITC-dextran (4.4 kDa) but were attenuated by Lactobacillus condition media (LCM) from both probiotic-strains.

  Effect

  Beneficial

  Effect size

  Moderate