Lactobacillus rhamnosus LRa05 and Improved Glycemia

Research synthesisVery low evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial moderate-sized effects of *Lactobacillus rhamnosus* LRa05 on glycemic outcomes. One randomized controlled trial in 80 adults with type 2 diabetes found statistically significant reductions in glycated hemoglobin and fasting plasma glucose. The evidence base is very small and should be considered preliminary.

Studied populations: adults with type 2 diabetes

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). One study is a correction notice with no original data, and a review provides general mechanistic support but does not present new trial evidence.

Generated Jul 12, 2026

3 of 3 papers

Multi-Strain Probiotics BLa80, LRa05, and BBr60 Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial.
- 2026-04
- RCT · n = 80
- Food science & nutrition 14(4)
- - Sijia Zhu
  - Yan Qiao
  - Wenjing He
  - Yaojie Xiao
  - Guiqin Song
  - Kang Liu
  - Shuguang Fang
- PubMed: 41971606
- DOI: 10.1002/fsn3.71735
11 Insights on
- Improved Glycemia
- High evidence
The probiotic group also exhibited significant reductions in total glycated hemoglobin (GHb) and fasting plasma glucose (FPG, p < 0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
not stated
Precision Microbiome Modulation: Exploring Lactobacillus spp. as A Targeted Strategy for Type 2 Diabetes Management.
- 2026-03-04
- Review
- Current nutrition reports 15(1)
- - Ann Sze Cheah
  - Ji Wei Tan
  - Faizul Jaafar
  - Wendy Wai Yeng Yeo
- PubMed: 41779301
- DOI: 10.1007/s13668-026-00739-3
4 Insights on
- Improved Glycemia
- Low evidence
Lactobacillus spp. supplementation alleviates insulin resistance in T2DM by modulating glucose metabolism and transport, exerting anti-inflammatory and anti-oxidative effects as well as restructuring gut microbiota.
Effect
Beneficial
Effect size
Moderate
Correction to "Lactobacillus rhamnosus LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes".
- 2025-11-15
- World journal of diabetes 16(11)
- - Lin Geng
  - Ting-Ting Sun
  - Wen-Bo Xia
  - Ying Qin
  - Di Huo
  - Guang-Jin Qu
- PubMed: 41278440
- DOI: 10.4239/wjd.v16.i11.114013
1 Insight on
- Improved Glycemia
- Low evidence
The correction notice refers to the article "Lactobacillus rhamnosus LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes," indicating the study assessed glycemic control outcomes in people with type 2 diabetes.
Effect
Beneficial
Effect size
Moderate

Lactobacillus rhamnosus LRa05 and Improved Glycemia

Multi-Strain Probiotics BLa80, LRa05, and BBr60 Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial.

Precision Microbiome Modulation: Exploring Lactobacillus spp. as A Targeted Strategy for Type 2 Diabetes Management.

Correction to "Lactobacillus rhamnosus LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes".