Lactobacillus rhamnosus VPro 11 and Beneficial Clinical Effects

• Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function.

  • 2004-12
  • The American Journal of Clinical Nutrition 80(6)
  • • H. Braat
    • Jan M. H. Van den Brande
    • E. V. van Tol
    • D. Hommes
    • M. Peppelenbosch
    • S. V. van Deventer

  • PubMed: 15585777
  • DOI: 10.1093/AJCN/80.6.1618

  7 Insights on

  • Beneficial Clinical Effects

  • Low evidence
  • Highly Cited
  • Clinical

  We propose that L. rhamnosus modulates DC function to induce a novel form of T cell hyporesponsiveness; this mechanism might be an explanation for the observed beneficial effects of probiotic treatment in clinical disease.

  Effect

  Beneficial

  Effect size

  Moderate