Lactobacillus rhamnosus and Improved Depressive Symptoms

• Microbiota basis of antidepressant effects of Zhi-zi-chi Decoction: Lactobacillus rhamnosus and gut microbiota metabolism.

  • 2025-10
  • Chinese herbal medicines 17(4)
  • • Jing He
    • Zixin Zhao
    • Ying Ye
    • Yujia Zhai
    • Dexun Yu
    • Fangyuan Gao
    • Jianlin Wu
    • Jun Wen
    • Tingting Zhou

  • PubMed: 41399797
  • DOI: 10.1016/j.chmed.2025.05.001

  3 Insights on

  • Improved Depressive Symptoms

  • Low evidence

  L. rhamnosus was demonstrated to increase the percentage of sucrose preference, reduce the immobility time in tail suspension and forced swimming tests, and alleviate depressive symptoms in rats.

  Effect

  Beneficial

  Effect size

  Moderate