Lactobacillus rhamnosus and Improved Gut Barrier Function

• Lacticaseibacillus rhamnosus attenuates uremic toxins in patients with nondialysis chronic kidney disease through the anti-inflammatory molecules.

  • 2025-07-31
  • RCT
  • Scientific reports 15(1)
  • • Asada Leelahavanichkul
    • Pornpimol Phuengmaung
    • Thansita Bhunyakarnjanarat
    • Warerat Kaewduangduen
    • Pimmada Boonnaj
    • Pichanan Tengamnuay
    • Wiwat Chancharoenthana
    • Somkanya Tungsanga
    • Suwasin Udomkarnjananun
    • Somying Tumwasorn

  • PubMed: 40744977
  • DOI: 10.1038/s41598-025-12768-z

  7 Insights on

  • Improved Gut Barrier Function

  • High evidence
  • Rigorous Journal

  attenuated several biomarkers, including... ii) gut permeability defect (beta-D-glucan but not by endotoxemia)

  Effect

  Beneficial

  Effect size

  Small

• Probiotic OMNi-BiOTiC® 10 AAD Reduces Cyclophosphamide-Induced Inflammation and Adipose Tissue Wasting in Mice.

  • 2023-08-20
  • n = 24
  • Nutrients 15(16)
  • • Beate Obermüller
    • Georg Singer
    • Bernhard Kienesberger
    • Barbara Mittl
    • Vanessa Stadlbauer
    • Angela Horvath
    • Wolfram Miekisch
    • Patricia Fuchs
    • Martina Schweiger
    • Laura Pajed
    • Holger Till
    • Christoph Castellani

  • PubMed: 37630845
  • DOI: 10.3390/nu15163655

  6 Insights on

  • Improved Gut Barrier Function

  • Low evidence
  • Rigorous Journal
  • Animal Study

  They showed significantly fewer pro-inflammatory cytokines and lower gut permeability compared to animals fed without the probiotic.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Development of Anti-inflammatory Probiotic Limosilactobacillus reuteri EFEL6901 as Kimchi Starter: in vitro and In vivo Evidence.

  • 2021-11-25
  • Frontiers in microbiology 12
  • • Hee Seo
    • Hyunbin Seong
    • Ga Yun Kim
    • Yu Mi Jo
    • Seong Won Cheon
    • Youngju Song
    • Byung Hee Ryu
    • Hee Kang
    • Nam Soo Han

  • PubMed: 34899643
  • DOI: 10.3389/fmicb.2021.760476

  3 Insights on

  • Improved Gut Barrier Function

  • Low evidence

  Analysis of these results indicated that EFEL6901 played a probiotic role by preventing the overproduction of pro-inflammatory cytokines, improving gut barrier function, and up-regulating the concentrations of short-chain fatty acids.

  Effect

  Beneficial

  Effect size

  Moderate