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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Lactobacillus rhamnosus and Improved Immune Function

Research synthesisLow evidenceMixed effect size4 studies · 4 beneficial · 0 neutral · 0 harmful

Across all 4 studies, 4 reported beneficial effects on immune function, with effect sizes mixed between small and moderate. Only 2 studies (one animal trial and one review) reached statistical significance. The evidence includes animal models and review-level data; no original human clinical trials were directly assessed, and no consistent dose or duration was reported.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The evidence base is small (only 4 studies) and includes mostly animal/in vitro studies and reviews; no original human clinical trials were identified. Doses and durations were not reported, limiting practical applicability. The two reviews suggest benefits in healthy adults, but the primary studies underlying them are not directly assessed here.

Generated May 19, 2026
4 of 4 papers
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