Lactobacillus rhamnosus and Improved Intestinal Barrier Function

• Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota.

  • 2025-04-05
  • Nutrients 17(7)
  • • Jinfeng Guo
    • Ying Zhao
    • Wenqian Guo
    • Yilin Sun
    • Wei Zhang
    • Qianyu Zhao
    • Yu Zhang
    • Yujun Jiang

  • PubMed: 40219029
  • DOI: 10.3390/nu17071272

  4 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Rigorous Journal

  It prevented LPS-induced TEER reduction in Caco-2 monolayers, decreased FITC-dextran permeability, restored intestinal microvilli integrity, and upregulated tight junction genes (ZO-1, occludin, claudin-1, and E-cadherin).

  Effect

  Beneficial

  Effect size

  Moderate

• Lactiplantibacillus plantarum NMGL2 exopolysaccharide ameliorates DSS-induced IBD in mice mainly by regulation of intestinal tight junction and NF-κB p65 protein expression.

  • 2024-10-28
  • Frontiers in microbiology 15
  • • Zengjia Zhou
    • Min Zhang
    • Mengke Yao
    • Jasra Naseeb
    • Abid Sarwar
    • Zhennai Yang
    • Tariq Aziz
    • Majid Alhomrani
    • Walaa F Alsanie
    • Abdulhakeem S Alamri

  • PubMed: 39529667
  • DOI: 10.3389/fmicb.2024.1491727

  4 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence

  significantly (p < 0.05) enhanced expression of ZO-1 and occludin

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction.

  • 2022-04-21
  • BMC immunology 23(1)
  • • Xi Yue
    • Sun Wen
    • Ding Long-Kun
    • Yan Man
    • Sun Chang
    • Zhang Min
    • Li Shuang-Yu
    • Qian Xin
    • Ma Jie
    • Wu Liang

  • PubMed: 35448938
  • DOI: 10.1186/s12865-022-00495-3

  2 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence

  The expressions of ZO-1 and Occludin in intestinal mucosa were significantly increased.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• A Multi-Strain Probiotic Formulation Improves Intestinal Barrier Function by the Modulation of Tight and Adherent Junction Proteins.

  • 2022-08-22
  • Cells 11(16)
  • • Raffaella di Vito
    • Carmela Conte
    • Giovanna Traina

  • PubMed: 36010692
  • DOI: 10.3390/cells11162617

  2 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence

  The probiotic formulation tested in this study modulates the expression of TJPs and prevents inflammatory damage. Our findings provide new insights into the mechanisms by which probiotics are able to prevent damage to the gut epithelial barrier.

  Effect

  Beneficial

  Effect size

  Moderate