Lactobacillus sakei proBio65 and Improved Skin Barrier Function

Research synthesisLow evidence3 studies · 3 beneficial · 0 neutral · 0 harmful

Two of three studies (both randomized controlled trials) reported beneficial effects of Lactobacillus sakei proBio65 on skin barrier function, with one showing a statistically significant increase in skin sebum content. The evidence is consistent but limited by small sample sizes and a moderate evidence base overall, with effect sizes described as small.

Studied populations: Japanese women aged 30-49 years; children and adolescents with atopic dermatitis

Caveats: One study (2025) is a review with no original data and low evidence score. Doses were not reported in any study, limiting dose-response conclusions. The clinical significance of observed small effects remains unclear.

Generated May 10, 2026

3 of 3 papers

Novel Application of Oral Postbiotics for Skin Condition in Healthy Middle-Aged Women: A Randomized, Double-Blind, and Placebo-Controlled Study.
- 2025-12
- RCT · n = 60
- Journal of cosmetic dermatology 24(12)
- - Jinko Sawashita
  - Shinichi Honda
  - Yuji Tominaga
  - Namiko Tomatsu
  - Jordi Espadaler-Mazo
  - Takahiro Ueda
- PubMed: 41414786
- DOI: 10.1111/jocd.70617
7 Insights on
- Improved Skin Barrier Function
- High evidence
Cheek skin moisture and transepidermal water loss improved for both groups after the intervention.
Effect
Beneficial
Effect size
Small
Oral Administration of Live and Dead Cells of Lactobacillus sakei proBio65 Alleviated Atopic Dermatitis in Children and Adolescents: a Randomized, Double-Blind, and Placebo-Controlled Study
- 2020-09-18
- RCT · n = 90
- Probiotics and Antimicrobial Proteins 13(2)
- - I. Rather
  - Byung-Chun Kim
  - L. Lew
  - S. Cha
  - Jong Hwan Lee
  - Gyeong-Jun Nam
  - R. Majumder
  - Jeongheui Lim
  - S. Lim
  - Y. Seo
  - Yong-Ha Park
- PubMed: 32949011
- DOI: 10.1007/s12602-020-09654-7
4 Insights on
- Improved Skin Barrier Function
- High evidence
The skin sebum content increased in both the live cell (p < 0.0001) and the dead cell group (p < 0.0001), suggesting potential improvements in skin barrier functions.
Effect
Beneficial
Effect size
Small
Significant
Yes
Postbiotics as Emerging Therapeutics for Skin Wound Healing and Dermatological Care: Clinical Trends and Mechanistic Insights.
- 2025-12
- Review
- International wound journal 22(12)
- - Seyedeh-Sara Hashemi
  - Alireza Rafati
  - Shahin Roohinejad
  - Fatemeh Yaghoobi
  - Alireza Salehi
- PubMed: 41381406
- DOI: 10.1111/iwj.70799
5 Insights on
- Improved Skin Barrier Function
- Low evidence
postbiotics were found to accelerate wound closure, stimulate collagen synthesis, and improve barrier integrity
Effect
Beneficial
Effect size
Small

Lactobacillus sakei proBio65 and Improved Skin Barrier Function

Novel Application of Oral Postbiotics for Skin Condition in Healthy Middle-Aged Women: A Randomized, Double-Blind, and Placebo-Controlled Study.

Oral Administration of Live and Dead Cells of Lactobacillus sakei proBio65 Alleviated Atopic Dermatitis in Children and Adolescents: a Randomized, Double-Blind, and Placebo-Controlled Study

Postbiotics as Emerging Therapeutics for Skin Wound Healing and Dermatological Care: Clinical Trends and Mechanistic Insights.