Across 3 studies, all reported beneficial effects of Lactobacillus sakei proBio65 on skin barrier function, with predominantly small effect sizes. The evidence includes two randomized controlled trials (RCTs) in middle-aged women and children with atopic dermatitis, and one review. One statistically significant finding was noted for increased skin sebum content. Doses, forms, and study durations were not consistently reported, limiting precise characterization.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Study durations and doses were not consistently reported, making it difficult to assess exposure-response relationships.
Cheek skin moisture and transepidermal water loss improved for both groups after the intervention.
The skin sebum content increased in both the live cell (p < 0.0001) and the dead cell group (p < 0.0001), suggesting potential improvements in skin barrier functions.
postbiotics were found to accelerate wound closure, stimulate collagen synthesis, and improve barrier integrity