Postbiotics as Emerging Therapeutics for Skin Wound Healing and Dermatological Care: Clinical Trends and Mechanistic Insights.

2025-12
International wound journal 22(12)
- Seyedeh-Sara Hashemi
- Alireza Rafati
- Shahin Roohinejad
- Fatemeh Yaghoobi
- Alireza Salehi

PubMed: 41381406
DOI: 10.1111/iwj.70799

Study Design

Type: Review
Methods: This review highlights the bioactive potential of postbiotics in modulating inflammation, enhancing tissue regeneration, and restoring microbiota balance in skin wounds. Through analysis of recent experimental and clinical studies...

Postbiotics, non-viable microbial components or metabolites derived from probiotics, represent a promising new class of therapeutic agents in dermatological and wound-healing science. This review highlights the bioactive potential of postbiotics in modulating inflammation, enhancing tissue regeneration, and restoring microbiota balance in skin wounds. Through analysis of recent experimental and clinical studies, postbiotics were found to accelerate wound closure, stimulate collagen synthesis, and improve barrier integrity while providing antimicrobial and immunomodulatory benefits. Their incorporation into topical formulations and wound dressings has shown to regulate moisture, prevent infection, and support optimal healing conditions. In contrast to live probiotics, postbiotics are stable, safe, and free from viability-related limitations, making them ideal for cosmetic and medical use. Overall, postbiotics represent an innovative, next-generation strategy for skin regeneration and wound management.

Research Insights

Lactobacillus acidophilus L-92→Improved Skin Barrier Function
postbiotics were found to accelerate wound closure, stimulate collagen synthesis, and improve barrier integrity
Effect
Beneficial
Effect size
Small
Lactobacillus acidophilus L-92→Improved Tissue Regeneration
This review highlights the bioactive potential of postbiotics in modulating inflammation, enhancing tissue regeneration, and restoring microbiota balance in skin wounds.
Effect
Beneficial
Effect size
Moderate
Lactobacillus acidophilus L-92→Improved Wound Healing
postbiotics were found to accelerate wound closure, stimulate collagen synthesis, and improve barrier integrity while providing antimicrobial and immunomodulatory benefits.
Effect
Beneficial
Effect size
Moderate
Lactobacillus sakei proBio65→Improved Skin Barrier Function
postbiotics were found to accelerate wound closure, stimulate collagen synthesis, and improve barrier integrity
Effect
Beneficial
Effect size
Small
Lactobacillus sakei proBio65→Improved Wound Healing
postbiotics were found to accelerate wound closure, stimulate collagen synthesis, and improve barrier integrity while providing antimicrobial and immunomodulatory benefits.
Effect
Beneficial
Effect size
Moderate
Lactobacillus sakei proBio65→Reduced Inflammation
This review highlights the bioactive potential of postbiotics in modulating inflammation, enhancing tissue regeneration, and restoring microbiota balance in skin wounds.
Effect
Beneficial
Effect size
Moderate