Lactobacillus salivarius LS-33 and Improved Intestinal Barrier Function

• Gut microbiome-derived indole-3-carboxaldehyde promotes intestinal development via AHR-NRF2 signaling in the early-life of chicks.

  • 2025-12-16
  • Clinical Trial
  • Microbiome 14(1)
  • • Yu-Xuan Huang
    • Zhang-Chao Deng
    • Ke-Xin Cao
    • Jia-Cheng Yang
    • Meng Liu
    • Ling Zhao
    • Jin-Shui Zheng
    • Lv-Hui Sun

  • PubMed: 41402846
  • DOI: 10.1186/s40168-025-02289-2

  2 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Rigorous Journal
  • Animal Study

  both bacteria (LG and LS) and metabolites (IAld and ICA) promoted epithelial barrier function

  Effect

  Beneficial

  Effect size

  Moderate

• Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-PARP1 Axis-Mediated DNA Repair to Mitigate Intestinal Aging.

  • 2025-10-28
  • Advanced science (Weinheim, Baden-Wurttemberg, Germany) 13(4)
  • • Zheng Cao
    • Cui Zhang
    • Hehua Lei
    • Weichuan Lin
    • Wenkai Yu
    • Xin Gao
    • Yanmeng He
    • Xinzhi Li
    • Qingwei Xiang
    • Zhiwen Zhang
    • Weifei Luo
    • Andrew D Patterson
    • Limin Zhang
    • Gang Chen

  • PubMed: 41147383
  • DOI: 10.1002/advs.202515794

  5 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence

  This interaction enhances intestinal barrier function and suppresses inflammation and cell senescence.

  Effect

  Beneficial

  Effect size

  Moderate