Lactobacillus salivarius SD-5208 and Regulated miR-130a-5p Levels

• Lactobacillus salivarius SNK-6 Regulates Liver Lipid Metabolism Partly via the miR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens

  • 2022-12-19
  • Clinical Trial
  • Cells 11(24)
  • • Lihui Zhu
    • R. Liao
    • Jiwen Huang
    • Changfeng Xiao
    • Yunzhou Yang
    • Huiying Wang
    • D. He
    • Huaxiang Yan
    • Changsuo Yang

  • PubMed: 36552896
  • DOI: 10.3390/cells11244133

  11 Insights on

  • Regulated miR-130a-5p Levels

  • Low evidence
  • Animal Study

  MBOAT2 (membrane-bound O-acyltransferase domain containing 2) was directly targeted by miR-130a-5p, which was downregulated in the liver of NAFLD laying hens but reversed after *L. salivarius* SNK-6 treatment.

  Effect

  Beneficial

  Effect size

  Moderate