Lactobacillus plantae Expressing Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Single-Chain Antibody Can Inhibit PRRSV Replication and Change the Intestinal Flora Structure of Piglets.
- 2025-03-03
- International journal of molecular sciences 26(5)
- Tianming Niu
- Tianqi Fan
- Yingjie Wang
- Kuipeng Gao
- Jinhui Zhao
- Ruyu Wang
- Xiaolei Chen
- Junhong Xing
- Jingjing Qiu
- Boshi Zou
- Shuhui Fan
- Shi Zhang
- Qiong Wu
- Guilian Yang
- Nan Wang
- Yan Zeng
- Xin Cao
- Yanlong Jiang
- Jianzhong Wang
- Haibin Huang
- Wentao Yang
- Chunwei Shi
- Zhipeng Li
- Chunfeng Wang
- PubMed: 40076879
- DOI: 10.3390/ijms26052257
- Low evidence
- Rigorous Journal
- Animal Study
In the piglet challenge protection test, the percentage of CD3+CD8+ T cells in the blood of piglets given complex lactic acid bacteria was significantly increased before and after the challenge (p < 0.01); the body temperature of piglets in this group was normal, the viral load of each organ was reduced, and the obvious pathological changes in each tissue were alleviated.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes