Lactobacillus salivarius UCC118 and Improved Insulin Sensitivity

• Probiotics improve glucose and lipid metabolism in pregnant women: a meta-analysis.

  • 2019-03
  • Meta-Analysis · n = 139
  • Annals of translational medicine 7(5)
  • • Man-Man Han
    • Jin-Fang Sun
    • Xiang-Hui Su
    • You-Fan Peng
    • Hemant Goyal
    • Chun-Hua Wu
    • Xiang-Yun Zhu
    • Ling Li

  • PubMed: 31019949
  • DOI: 10.21037/atm.2019.01.61

  4 Insights on

  • Improved Insulin Sensitivity

  • High evidence

  probiotics supplementation effectively reduced the fasting blood glucose (FBG) levels ... serum insulin levels ... insulin resistance (HOMA-IR).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• The Effects of Probiotics/Synbiotics on Glucose and Lipid Metabolism in Women with Gestational Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials.

  • 2023-03-12
  • Meta-Analysis · n = 11
  • Nutrients 15(6)
  • • Jinhao Mu
    • Xian Guo
    • Yanbing Zhou
    • Guoxia Cao

  • PubMed: 36986107
  • DOI: 10.3390/nu15061375

  6 Insights on

  • Improved Insulin Sensitivity

  • High evidence
  • Rigorous Journal

  Compared with the placebo, probiotics/synbiotics were associated with a statistically significant improvement in HOMA-IR (MD = -0.40, 95% CI = -0.74, -0.06, p = 0.02)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Improvement of glucose metabolism in pregnant women through probiotic supplementation depends on gestational diabetes status: meta-analysis.

  • 2020-10-20
  • Meta-Analysis
  • Scientific reports 10(1)
  • • Karolina Łagowska
    • Anna M Malinowska
    • Bogna Zawieja
    • Emilia Zawieja

  • PubMed: 33082439
  • DOI: 10.1038/s41598-020-74773-8

  5 Insights on

  • Improved Insulin Sensitivity

  • High evidence
  • Rigorous Journal

  both probiotics and synbiotics lower serum insulin level and HOMA-IR index

  Effect

  Beneficial

  Effect size

  Moderate

• The dietary supplements effect on metabolic markers in non-pharmacologically managed gestational diabetes mellitus patients: a systematic review and meta-analysis and meta-regression of randomized controlled trials.

  • 2023-12-30
  • Meta-Analysis
  • Journal of diabetes and metabolic disorders 23(1)
  • • Sumanta Saha
    • Sujata Saha
    • Mohan Gayen

  • PubMed: 38932907
  • DOI: 10.1007/s40200-023-01369-0

  8 Insights on

  • Improved Insulin Sensitivity

  • High evidence

  Meta-analysis showed favorable effects of dietary supplementation on ... homeostasis model assessment indexes- insulin resistance (HOMA-IR; WMD: -1.02, p < 0.001)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• The role of probiotics and synbiotics on treatment of gestational diabetes: systematic review and meta-analysis.

  • 2024-02
  • Review · n = 896
  • AJOG global reports 4(1)
  • • Arresta Vitasatria Suastika
    • I Gde Raka Widiana
    • Ni Nengah Dwi Fatmawati
    • Ketut Suastika
    • Ivana Beatrice Paulus
    • I Nengah Sujaya

  • PubMed: 38322777
  • DOI: 10.1016/j.xagr.2023.100285

  9 Insights on

  • Improved Insulin Sensitivity

  • High evidence

  individuals with probiotic had significant reduction on homeostasis model assessment insulin resistance (mean difference, -0.72; 95% confidence interval, -1.07 to -0.38)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity.

  • 2024-04-30
  • Review
  • Nutrients 16(9)
  • • A K M Humayun Kober
    • Sudeb Saha
    • Mutamed Ayyash
    • Fu Namai
    • Keita Nishiyama
    • Kazutoyo Yoda
    • Julio Villena
    • Haruki Kitazawa

  • PubMed: 38732619
  • DOI: 10.3390/nu16091373

  10 Insights on

  • Improved Insulin Sensitivity

  • Moderate evidence
  • Rigorous Journal

  Furthermore, probiotics effectively increase insulin sensitivity and decrease systemic inflammation.

  Effect

  Beneficial

  Effect size

  Moderate