Research synthesisModerate evidenceModerate effect6 studies · 6 beneficial · 0 neutral · 0 harmful
Across 6 studies (all meta-analyses or reviews), all reported beneficial moderate-sized effects on insulin sensitivity, primarily in pregnant women with gestational diabetes. The evidence consistently shows improvements in HOMA-IR and fasting insulin levels. However, no studies specifically tested Lactobacillus salivarius UCC118 as a single strain, and no dose or form data were extracted.
- Studied populations: pregnant women, especially those with gestational diabetes mellitus (GDM)
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The studies evaluated mixed probiotics, not specifically L. salivarius UCC118, so the effect of this particular strain is unclear. All evidence comes from pregnant or GDM populations, limiting generalizability to other groups. No consistent dose or supplement form data were reported across studies.
Generated May 12, 2026