Lactobacillus salivarius UCC118 and Reduced Gastrointestinal Infections

Research synthesisVery low evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 review-level studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on reducing gastrointestinal infections, with effect sizes ranging from small to moderate. No human trial data were available; the evidence is derived from animal models and genomic characterizations. Doses, forms, and study durations were not reported.

Caveats: All studies are reviews or genomic reports, not original controlled human trials. Evidence comes from mouse models of Listeria infection and in vitro bacteriocin characterization, so direct translation to human gastrointestinal infections is uncertain. No human-specific dosing, form, or population data were extracted.

Generated May 11, 2026

3 of 3 papers

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations.
- 2020-09-02
- Review
- FEMS microbiology reviews 45(1)
- - Samira Soltani
  - Riadh Hammami
  - Paul D Cotter
  - Sylvie Rebuffat
  - Laila Ben Said
  - Hélène Gaudreau
  - François Bédard
  - Eric Biron
  - Djamel Drider
  - Ismail Fliss
- PubMed: 32876664
- DOI: 10.1093/femsre/fuaa039
3 Insights on
- Reduced Gastrointestinal Infections
- Moderate evidence
- Highly Cited
Lactobacillus salivarius UCC118 ... was shown to confer a protective effect against Listeria infection in a mouse model.
Effect
Beneficial
Effect size
Small
Exploring the bioactive landscape: peptides and non-peptides from the human microbiota.
- 2025-05-08
- Review
- NPJ biofilms and microbiomes 11(1)
- - Abdul Bari Shah
  - Hyeonjae Cho
  - Sang Hee Shim
- PubMed: 40341751
- DOI: 10.1038/s41522-025-00713-x
3 Insights on
- Reduced Gastrointestinal Infections
- Low evidence
Lactobacillus salivarius UCC118 has been shown to confer protection against gastrointestinal infection through the production of a bacteriocin, Abp118.
Effect
Beneficial
Effect size
Moderate
Whole-Genome Sequence of Lactobacillus salivarius DJ-sa-01, Isolated from Chicken Small Intestine.
- 2018-10-11
- Microbiology resource announcements 7(14)
- - Dongjun Kim
  - Mun-Ju Cho
  - Seungchan Cho
  - Yongjun Lee
  - Sung June Byun
  - Sukchan Lee
- PubMed: 30533717
- DOI: 10.1128/mra.00987-18
3 Insights on
- Reduced Gastrointestinal Infections
- Low evidence
Lactobacillus salivarius UCC118 has been shown to confer health benefits and protect against gastrointestinal infection
Effect
Beneficial
Effect size
Moderate

Lactobacillus salivarius UCC118 and Reduced Gastrointestinal Infections

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations.

Exploring the bioactive landscape: peptides and non-peptides from the human microbiota.

Whole-Genome Sequence of Lactobacillus salivarius DJ-sa-01, Isolated from Chicken Small Intestine.