Lactobacillus salivarius UCC118 and Reduced Gastrointestinal Infections

Research synthesisVery low evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 for reducing gastrointestinal infections, with effect sizes ranging from small to moderate. The evidence is drawn entirely from review articles and a genomic study, with no human trials or doses consistently reported.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All studies are reviews or genomic analyses, not primary human intervention trials; no doses, durations, or statistical significance data are reported. The beneficial findings are based on animal models and mechanistic plausibility, not clinical human data.

Generated May 12, 2026

3 of 3 papers

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations.
- 2020-09-02
- Review
- FEMS microbiology reviews 45(1)
- - Samira Soltani
  - Riadh Hammami
  - Paul D Cotter
  - Sylvie Rebuffat
  - Laila Ben Said
  - Hélène Gaudreau
  - François Bédard
  - Eric Biron
  - Djamel Drider
  - Ismail Fliss
- PubMed: 32876664
- DOI: 10.1093/femsre/fuaa039
3 Insights on
- Reduced Gastrointestinal Infections
- Moderate evidence
- Highly Cited
Lactobacillus salivarius UCC118 ... was shown to confer a protective effect against Listeria infection in a mouse model.
Effect
Beneficial
Effect size
Small
Exploring the bioactive landscape: peptides and non-peptides from the human microbiota.
- 2025-05-08
- Review
- NPJ biofilms and microbiomes 11(1)
- - Abdul Bari Shah
  - Hyeonjae Cho
  - Sang Hee Shim
- PubMed: 40341751
- DOI: 10.1038/s41522-025-00713-x
3 Insights on
- Reduced Gastrointestinal Infections
- Low evidence
Lactobacillus salivarius UCC118 has been shown to confer protection against gastrointestinal infection through the production of a bacteriocin, Abp118.
Effect
Beneficial
Effect size
Moderate
Whole-Genome Sequence of Lactobacillus salivarius DJ-sa-01, Isolated from Chicken Small Intestine.
- 2018-10-11
- Microbiology resource announcements 7(14)
- - Dongjun Kim
  - Mun-Ju Cho
  - Seungchan Cho
  - Yongjun Lee
  - Sung June Byun
  - Sukchan Lee
- PubMed: 30533717
- DOI: 10.1128/mra.00987-18
3 Insights on
- Reduced Gastrointestinal Infections
- Low evidence
Lactobacillus salivarius UCC118 has been shown to confer health benefits and protect against gastrointestinal infection
Effect
Beneficial
Effect size
Moderate

Lactobacillus salivarius UCC118 and Reduced Gastrointestinal Infections

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations.

Exploring the bioactive landscape: peptides and non-peptides from the human microbiota.

Whole-Genome Sequence of Lactobacillus salivarius DJ-sa-01, Isolated from Chicken Small Intestine.