Exploring the bioactive landscape: peptides and non-peptides from the human microbiota.
- 2025-05-08
- NPJ biofilms and microbiomes 11(1)
- Abdul Bari Shah
- Hyeonjae Cho
- Sang Hee Shim
- PubMed: 40341751
- DOI: 10.1038/s41522-025-00713-x
Study Design
- Type
- Review
- Methods
- This review explores their structures and functions
The human microbiota, consisting of trillions of bacteria from six main phyla, produces peptide and non-peptide secondary metabolites which have antibacterial properties vital to medicine and biotechnology. These metabolites influence biological processes linked to diseases, yet much remains unknown. This review explores their structures and functions, aiming to spur novel metabolite discovery and advance drug development.
Research Insights
Lactobacillus salivarius UCC118 has been shown to confer protection against gastrointestinal infection through the production of a bacteriocin, Abp118.
- Effect
- Beneficial
- Effect size
- Moderate