Lactobacillus salivarius UCC118 and Reduced Risk of Infection

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies (all review articles), all reported moderate beneficial effects of Lactobacillus salivarius UCC118 on reducing risk of infection. No studies reported statistical significance. Dose, duration, form, and population were not consistently reported across studies.

Caveats: All three studies are reviews, not original clinical trials, and none reported statistical significance. Evidence base is small (only 3 studies), and available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias. Conclusions should be considered preliminary.

Generated May 12, 2026

3 of 3 papers

Bacteriocins from Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine.
- 2021-04-01
- Review
- Animals : an open access journal from MDPI 11(4)
- - Juan Carlos Hernández-González
  - Abigail Martínez-Tapia
  - Gebim Lazcano-Hernández
  - Blanca Estela García-Pérez
  - Nayeli Shantal Castrejón-Jiménez
- PubMed: 33915717
- DOI: 10.3390/ani11040979
5 Insights on
- Reduced Risk of Infection
- Moderate evidence
- Highly Cited
Lactobacillus salivarius UCC118 ... has been shown to protect against bacterial pathogens and improve health in animal models and humans.
Effect
Beneficial
Effect size
Moderate
Role and Mechanisms of Gut Microbiota in Infectious Diseases: Recent Evidence from Animal Models.
- 2026-01-30
- Review
- Biology 15(3)
- - Tao Zeng
  - Linxue Zuo
  - Qiaorui Yu
  - Qiurui Wu
  - Zhiru Bao
  - Hairong Xiong
  - Mei Luo
  - Bei Li
- PubMed: 41677726
- DOI: 10.3390/biology15030256
4 Insights on
- Reduced Risk of Infection
- Low evidence
commensal microbes and their metabolites confer protection against enteric and respiratory infections
Effect
Beneficial
Effect size
Moderate
Gut-Antimicrobial Peptides: Synergistic Co-Evolution with Antibiotics to Combat Multi-Antibiotic Resistance.
- 2023-12-14
- Review
- Antibiotics (Basel, Switzerland) 12(12)
- - Piyush Baindara
  - Santi M Mandal
- PubMed: 38136766
- DOI: 10.3390/antibiotics12121732
2 Insights on
- Reduced Risk of Infection
- Low evidence
Lactobacillus salivarius UCC118... has been shown to protect against a range of pathogens in the gastrointestinal tract
Effect
Beneficial
Effect size
Moderate

Lactobacillus salivarius UCC118 and Reduced Risk of Infection

Bacteriocins from Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine.

Role and Mechanisms of Gut Microbiota in Infectious Diseases: Recent Evidence from Animal Models.

Gut-Antimicrobial Peptides: Synergistic Co-Evolution with Antibiotics to Combat Multi-Antibiotic Resistance.