Bacteriocins from Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine.

2021-04-01
Animals : an open access journal from MDPI 11(4)
- Juan Carlos Hernández-González
- Abigail Martínez-Tapia
- Gebim Lazcano-Hernández
- Blanca Estela García-Pérez
- Nayeli Shantal Castrejón-Jiménez

PubMed: 33915717
DOI: 10.3390/ani11040979

Study Design

Type: Review
Methods: This review shows the advances in applying bacteriocins in animal production and veterinary medicine

Highly Cited

In the search for an alternative treatment to reduce antimicrobial resistance, bacteriocins shine a light on reducing this problem in public and animal health. Bacteriocins are peptides synthesized by bacteria that can inhibit the growth of other bacteria and fungi, parasites, and viruses. Lactic acid bacteria (LAB) are a group of bacteria that produce bacteriocins; their mechanism of action can replace antibiotics and prevent bacterial resistance. In veterinary medicine, LAB and bacteriocins have been used as antimicrobials and probiotics. However, another critical role of bacteriocins is their immunomodulatory effect. This review shows the advances in applying bacteriocins in animal production and veterinary medicine, highlighting their biological roles.

Research Insights

Lactobacillus salivarius UCC118→Improved Gastrointestinal Health
Lactobacillus salivarius UCC118 ... can inhibit the growth of other bacteria and fungi, parasites, and viruses ... [and] have been used as antimicrobials and probiotics.
Effect
Beneficial
Effect size
Small
Lactobacillus salivarius UCC118→Improved Immune Function
another critical role of bacteriocins is their immunomodulatory effect
Effect
Beneficial
Effect size
Small
Lactobacillus salivarius UCC118→Improved Immune Response
It has also been reported to modulate the immune system, contributing to improved host defense and health.
Effect
Beneficial
Effect size
Small
Lactobacillus salivarius UCC118→Reduced Pathogen Colonization
Lactobacillus salivarius UCC118 has been shown to reduce the colonization of pathogenic bacteria in the intestinal tract and to protect the host from infection.
Effect
Beneficial
Effect size
Moderate
Lactobacillus salivarius UCC118→Reduced Risk of Infection
Lactobacillus salivarius UCC118 ... has been shown to protect against bacterial pathogens and improve health in animal models and humans.
Effect
Beneficial
Effect size
Moderate