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Evidence-Based Supplement Research
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Lactobacillus salivarius UCC118 and Improved Gastrointestinal Health

Research synthesisVery low evidenceMixed effect size10 studies · 10 beneficial · 0 neutral · 0 harmful

Across 10 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on gastrointestinal health, with effect sizes ranging from small to moderate. The majority of studies (6 of 10) reported small effects, while 3 reported moderate effects and 1 did not specify an effect size. All studies were review articles or non-clinical reports; no human trials with statistical significance were identified. No consistent dose range, form, or study duration was reported across the studies.

  • Studied populations: athletes and physically active individuals (one study); general healthy adults and animal models referenced but no specific populations confirmed in controlled trials

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. All included papers are reviews, case reports, or genomic characterization studies; no RCTs or controlled human trials with measured outcomes were present. No study reported a specific dose, duration, or formulation tested in humans, limiting actionable conclusions.

Generated May 12, 2026
10 of 10 papers
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