Lactococcus cremoris VPro 41 and Enhanced IFN-γ Production

• Lactococcus lactis subsp. cremoris FC triggers IFN-γ production from NK and T cells via IL-12 and IL-18.

  • 2012-12
  • Clinical Trial
  • International Immunopharmacology 14(4)
  • • A. Kosaka
    • Huimin Yan
    • S. Ohashi
    • Yayoi Gotoh
    • Ami Sato
    • H. Tsutsui
    • T. Kaisho
    • T. Toda
    • N. Tsuji

  • PubMed: 23102661
  • DOI: 10.1016/j.intimp.2012.10.007

  8 Insights on

  • Enhanced IFN-γ Production

  • Low evidence
  • Animal Study

  Consequently, LcFC triggered IFN-γ production in splenic NK, CD8(+), and CD4(+) cells. Most prominent effect of LcFC on IFN-γ production was observed in NK cells.

  Effect

  Beneficial

  Effect size

  Large